Organonitrogen Compounds
Tertiary amines
(2,282)
Secondary amines
(2,225)
Alkanolamines
(1,942)
Quaternary ammonium salts
(1,660)
Primary amines
(1,423)
Isocyanates
(1,266)
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Medchemexpress LLC Guanidine hydrochloride | 50-01-1 | 98.0% | 25 G
Guanidine hydrochloride is a strong chaotrope and denaturant of proteins, widely used in biochemical research. It causes co-operative unfolding of the molten globule state at high concentrations and can refold acid-unfolded proteins at low concentrations.
- Induces co-operative unfolding of the molten globule state at concentrations greater than 1 M.
- Refolds acid-unfolded apomyoglobin and cytochrome c at low concentrations.
- Stabilizes the molten globule state.
- Does not affect disulfide bonds.
- Can cause efficient loss of the [PSI+] element from yeast cells at millimolar concentrations.
- Reduces Hsp104-mediated basal and acquired thermotolerance.
- Reduces Hsp104's ability to restore activity of thermally denatured luciferase.
- In vivo, significantly reduces the death rate of infant mice infected with coxsackievirus A16.
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Medchemexpress LLC Bx430 | 688309-70-8 | 99.2% | 413.11 | 50MG
BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. It exhibits species specificity and is utilized for chronic pain and cardiovascular disease.
- Potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist.
- IC50 of 0.54 μM against P2X4 receptor channels.
- Exhibits species specificity.
- Has virtually no functional impact on other P2X subtypes (P2X1-P2X3, P2X5, and P2X7).
- Potent antagonist of zebrafish P2X4 but no effect on rat and mouse P2X4 orthologs.
- Used for chronic pain and cardiovascular disease.
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